Prostate Cancer
Data from Purdue University advance knowledge in prostate cancer
Published in Cancer Weekly, August 11th, 2009
"The high mortality and financial burden associated with prostate cancer can be partly attributed to a lack of sensitive screening methods for detection and staging of the disease. Guided by in silico docking studies using the crystal structure of PSMA, we designed and synthesized a series of PSMA-targeted Tc-99m-chelate complexes for imaging PSMA-expressing human prostate cancer cells (LNCaP cell line)," scientists in the United States report.
"Of the six targeted radioimaging agents synthesized, three were found to bind LNCaP cells with low nanomolar affinity. Moreover, the same three PSMA-targeted imaging agents were shown to localize primarily to LNCaP tumor...
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Source: Cancer Weekly (2009-08-11)
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