Cancer Genetics
Reports summarize cancer genetics study results from Yonsei University, Department of Pathology
Published in Cancer Weekly, August 11th, 2009
Investigators publish new data in the report 'Non-histone nuclear factor HMGB1 is phosphorylated and secreted in colon cancers.' "The high mobility group box 1 (HMGB1) protein, a non-histone nuclear factor, is overexpressed and localizes to the cytoplasm in some cancer cells. However, the mechanism of cytoplasmic HMGB1 transport, extracellular secretion, and its role in cancer progression is not clear," researchers in Seoul, Korea report.
"To simulate the activated state of HMGB1, we mutated serine residues of nuclear localization signals (NLSs) to glutamic acid and performed transfection assays. We carried out a kinase inhibitor study and evaluated the cell migration...
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Source: Cancer Weekly (2009-08-11)
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