Breast Cancer

Studies from M.H. Yun et al have provided new data on breast cancer

Published in Cancer Weekly, August 11th, 2009

According to recent research published in the journal Biochemical Society Transactions, "Inheritance of a mutation in BRCA1 (breast cancer 1 early-onset) results in predisposition to early-onset breast and ovarian cancer. Tumours in these individuals arise after somatic mutation or loss of the wild-type allele."

"Loss of BRCA1 function leads to a profound increase in genomic instability involving the accumulation of mutations, DNA breaks and gross chromosomal rearrangements. Accordingly, BRCA1 has been implicated as an important factor involved in both the repair of DNA lesions and in the regulation of cell-cycle checkpoints in response to DNA damage," wrote M.H....

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Source: Cancer Weekly (2009-08-11)

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