Squamous Cell Carcinoma

Reports summarize squamous cell carcinoma study results from University of Hawaii

Published in Cancer Weekly, August 18th, 2009

"Models of epidermal carcinogenesis have demonstrated that Ras is a critical molecule involved in tumor initiation and progression. Previously, we have shown that RasGRP1 increases the susceptibility of mice to skin tumorigenesis when overexpressed in the epidermis by a transgenic approach, related to its ability to activate Ras," investigators in the United States report.

"Moreover, RasGRP1 transgenic mice develop spontaneous papillomas and cutaneous squamous cell carcinomas, some of which appear to originate in sites of injury, suggesting that RasGRP1 may be responding to signals generated during the wound-heating process. in this study, we examined the response of...

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Source: Cancer Weekly (2009-08-18)

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