Leukemia Genetics
University of Luxembourg describes research in leukemia genetics
Published in Cancer Weekly, September 8th, 2009
Research findings, 'SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling,' are discussed in a new report. According to a study from Luxembourg, "Recently, mutations in the gene of Janus kinase 2 (Jak2) were discovered in patients suffering from chronic myeloproliferative disorders (MPD) and leukemia. As suppressors of cytokine signaling (SOCS) proteins are potent feedback inhibitors of Jak-mediated signaling, we investigated their role in signal transduction through constitutively active Jak2 mutants."
"We selected two mutants, Jak2-V617F and Jak2-K539L, found in patients with MPDs and Jak2-T875N identified in...
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Source: Cancer Weekly (2009-09-08)
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