Cell Motility

Research from J. Qian et al has provided new information about cell motility

Published in Cancer Weekly, September 22nd, 2009

"We aimed to investigate the potential modification of previously unrecognized surface glycoprotein(s) by alpha 2,6-sialylation other than by integrins. The expression of beta-galactoside alpha 2,6-sialyltransferase (ST6Gal-I) in the colon cancer cell line HCT116 was reduced by siRNA," investigators in Shanghai, People's Republic of China report.

"The adhesion and Boyden chamber assay were used to detect the variation in cell motility. alpha 2,6-Sialylation proteins were detected with lectin affinity assay. The mRNA expression, protein expression and downstream signaling modulation with siRNA were detected using reverse transcription-polymerase chain reaction, flow...

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Source: Cancer Weekly (2009-09-22)

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