Colon Cancer
Scientists at Autonomous University target colon cancer
Published in Cancer Weekly, October 6th, 2009
"The active vitamin D metabolite 1 alpha,25-dihydroxyvitamin D-3 [1 alpha,25(OH)(2)D-3] has wide but not fully understood antitumor activity. A previous transcriptomic analysis of 1 alpha,25(OH)(2)D-3 action on human colon cancer cells revealed cystatin D (CST5), which encodes an inhibitor of several cysteine proteases of the cathepsin family, as a candidate target gene," scientists writing in the Journal of Clinical Investigation report.
"Here we report that 1 alpha,25(OH)(2)D-3 induced vitamin D receptor (VDR) binding to, and activation of, the CST5 promoter and increased CST5 RNA and protein levels in human colon cancer cells. In cells lacking endogenous...
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Source: Cancer Weekly (2009-10-06)
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