Cancer Gene Therapy
Reports outline cancer gene therapy study findings from S. Terao and colleagues
Published in Cancer Weekly, October 13th, 2009
According to recent research from Nishinomiya, Japan, "The transduction efficacy of adenovirus serotype 5 (Ad5) vector in human renal carcinoma cells is generally extremely low due to the non-expression of Coxsackie and adenoviral receptor (CAR). We investigated whether fiber-modified Ad vector containing an RGD motif in the HI loop of the Ad fiber knob could increase the transduction efficiency of Ad5 in human renal carcinoma cells in vitro."
"We examined both expressions of CAR, and alpha(v), beta(3) and beta(5) integrins, and the transduction efficacy of fiber-modified adenovirus vector in all cell lines. The expression of CAR was lower and those of av and beta(3)...
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Source: Cancer Weekly (2009-10-13)
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