Genetics

New findings from V. Srivastava and co-authors describe advances in genetics

Published in Cancer Weekly, October 20th, 2009

According to a study from New Delhi, India, "Mutation of BLM helicase results in the autosomal recessive disorder Bloom syndrome (BS). with BS exhibit hyper-recombination and are prone to almost all forms of cancer."

"BLM can exhibit its anti-recombinogenic function either by dissolution of double Holliday junctions or by disruption of RAD51 nucleofilaments. We have now found that BLM can interact with the pro-recombinogenic protein RAD54 through an internal ten-residue polypeptide stretch in the N-terminal region of the helicase. The N-terminal region of BLM prevented the formation of RAD51-RAD54 complex, both in vitro and in vivo. Using the fluorescence recovery after...

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Source: Cancer Weekly (2009-10-20)

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