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Data on cancer reported by researchers at University of Virginia, Department of Urology

Published in Cancer Weekly, October 20th, 2009

Fresh data on cancer are presented in the report 'The role of SPARC in the TRAMP model of prostate carcinogenesis and progression.' "SPARC (Secreted Protein Acidic and Rich in Cysteine), is a matricellular glycoprotein that is produced by tumor and/or neighboring stroma. In human prostate cancer, SPARC immunoreactivity is highest in metastatic lesions but distinct contributions of tumoral and stromal SPARC to tumorigenesis and progression are unclear," researchers in the United States report.

"To determine the role of SPARC in primary prostate tumorigenesis, we crossed SPARC-null (SP(-/-)) with TRAMP (Transgenic Adenocarcinoma of Mouse Prostate) mice. TRAMP(+)/SP(-/-)...

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