Gene Therapy

New gene therapy study results from INSERM described

Published in Cancer Weekly, October 20th, 2009

New research, 'ING2 controls the progression of DNA replication forks to maintain genome stability,' is the subject of a report. "Inhibitor of growth 2 (ING2) is a candidate tumor suppressor gene the expression of which is frequently lost in tumours. Here, we identified a new function for ING2 in the control of DNA replication and in the maintenance of genome stability," scientists in Grenoble, France report.

"Global replication rate was markedly reduced during normal S-phase in small interfering RNA (siRNA) ING2 cells, as seen in a DNA fibre spreading experiment. Accordingly, we found that ING2 interacts with proliferating cell nuclear antigen and regulates its amount...

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Source: Cancer Weekly (2009-10-20)

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