Cancer Gene Therapy

New cancer gene therapy research from K.J. Zhang and co-researchers described

Published in Cancer Weekly, October 20th, 2009

"Interleukin (IL)-24 is an excellent therapeutic gene for cancer therapy. In this work, IL-24 was inserted into Ad.sp-E1A((Delta 24)), an oncolytic adenovirus with a 24-bp deletion in the E1A gene, which was driven by the survivin promoter to form Ad.sp-E1A((Delta 24))-IL-24," scientists in Shanghai, People's Republic of China report.

"Ad.sp-E1A((Delta 24))-IL-24 has an excellent antitumor effect in vitro for human nasopharyngeal, liver, lung, and cervical carcinoma cell lines but does no or little damage to normal cell lines L-02 and WI38. Furthermore, it achieved nearly complete inhibition (although not elimination) of NCI-H460 lung carcinoma growth in nude mice. The...

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Source: Cancer Weekly (2009-10-20)

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