Colon Cancer

New colon cancer research has been reported by A. Boquoi et al

Published in Cancer Weekly, October 27th, 2009

According to recent research published in the journal Cancer Prevention Research, "Despite advances in screening and treatment, colorectal cancer remains the second leading cause of cancer-related death in the United States. Cyclin-dependent kinases (Cdk) are deregulated in colorectal cancer by silencing of the Cdk inhibitor p16(Ink4a) and other mechanisms."

"We tested whether the small molecule Cdk inhibitor SNS-032 (formerly BMS-387032), which targets Cdk2, Cdk7, and Cdk9, can prevent intestinal tumorigenesis in mouse models. We generated mice with high intestinal tumor loads by combining the multiple intestinal neoplasia (Min) mutation with Ink4a/Arf mutations...

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Source: Cancer Weekly (2009-10-27)

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