Prostate Cancer
Scientists at University Hospital target prostate cancer
Published in Cancer Weekly, October 27th, 2009
According to recent research published in the journal Cancer Epidemiology Biomarkers & Prevention, "Genetic predisposition to prostate cancer includes multiple common variants with a low penetrance (single nucleotide polymorphisms) and rare variants with higher penetrance. The mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 are associated with Lynch syndrome where colon and endometrial cancers are the predominant phenotypes."
"The purpose of our study was to investigate whether germ-line mutations in these genes may be associated with prostate cancer. One hundred and six male carriers or obligate carriers of MMR mutations were identified. Nine had...
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Source: Cancer Weekly (2009-10-27)
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