Life Sciences

Research in the area of life sciences reported from University of Michigan

Published in Cancer Weekly, December 8th, 2009

"Poly(amidoamine) (PAMAM) dendrons were synthesized with c(RGDyK) peptide on the surface to create a scaffold for cellular targeting and multivalent binding. Binary dendron-RGD conjugates were synthesized with a single Alexa Fluor 488, biotin, methotrexate drug molecule, or additional functionalized dendron at the focal point," scientists in the United States report.

"The targeted dendron platform was shown to specifically target alpha(V)beta(3) integrin expressing human umbilical vein endothelial cells (HUVEC) and human glioblastoma cells (U87MG) in vitro via flow cytometry. Specific targeting of the dendron-RGD platform was further confirmed by confocal microscopy....

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Source: Cancer Weekly (2009-12-08)

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