Renal Cell Carcinoma
Research findings from Cleveland Clinic update understanding of renal cell carcinoma
Published in Cancer Weekly, December 8th, 2009
According to a study from the United States, "Increased expression of gangliosides by different tumor types including renal cell carcinoma (RCC) is thought to contribute to the immune suppression observed in cancer patients. In this study, we report an increase in apoptotic T cells from RCC patients compared with T cells from normal donors that coincided with the detection of T cells staining positive for GM2 and that the apoptosis was predominantly observed in the GM2(+) but not the GM2(-) T cell population."
"Ganglioside shedding from tumor rather than endogenous production accounts for GM2(+) T cells since there was no detectable level of mRNA for GM2 synthase in RCC...
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Source: Cancer Weekly (2009-12-08)
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