Immunology
Reports from Clinical Research Institute of Montreal highlight recent research in immunology
Published in Cancer Weekly, December 8th, 2009
Fresh data on immunology are presented in the report 'Importance and mechanism of 'switch' function of SAP family adapters.' According to a study from Montreal, Canada, "The signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) family of adapters includes SAP, Ewing's sarcoma-associated transcript-2 (EAT-2), and EAT-2-related transducer (ERT). These Src homology-2 (SH2) domain-only molecules play critical roles in immune regulation."
"The prototype of the SAP family, SAP, is mutated in X-linked lymphoproliferative disease in humans. Moreover, genetically engineered mice lacking one or more SAP family members have defects in multiple immune cell types...
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Source: Cancer Weekly (2009-12-08)
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