Glioblastoma
Researchers at University of Leipzig, Institute of Biochemistry target glioblastoma
Published in Cancer Weekly, December 22nd, 2009
Research findings, 'The PFKFB3 splice variant UBI2K4 is downregulated in high-grade astrocytomas and impedes the growth of U87 glioblastoma cells,' are discussed in a new report. According to recent research from Germany, "Fructose-2,6-bisphosphate, a key regulator of glycolysis, is synthesized and degraded by four different isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1-4). The PFKFB3 isozyme is upregulated in several human tumours."
"Six alternatively spliced variants of PFKFB3 mRNA are known in humans (UBI2K1-6). Here, we studied the role of the PFKFB3 splice variants in human astrocytic gliomas. We analysed the PFKFB3 splice variants in 48...
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Source: Cancer Weekly (2009-12-22)
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