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Research

New hope for diagnosis and treatment of intractable pediatric brain tumors

Published in Cancer Weekly, December 22nd, 2009

Scientists have discovered oncogenes capable of driving growth of normal human brain stem cells in a highly malignant pediatric brain tumor. The research, published by Cell Press in the December issue of the journal Cancer Cell, has significant implications for clinical management of aggressive pediatric brain tumors that are notorious for their dismal prognosis.

Primitive neuroectodermal tumors (PNETs) arise from undifferentiated brain cells and are the most frequent malignant brain tumors in children. There are different forms of PNETs and, while scientists have made progress in characterizing the genetic abnormalities associated with some PNET subtypes, the highly...

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