Human Papillomavirus

Research from W.C. Spanos and co-researchers provides new data on human papillomavirus

Published in Cancer Weekly, December 29th, 2009

"Human papillomavirus (HPV) is the most identifiable cause of head and neck squamous cell cancer (HNSCC). Compared with HPV-negative HNSCC, HPV-positive HNSCC presents at an advanced stage but with significantly better survival," scientists in the United States report.

"We created a syngeneic mouse model of HPV-positive and HPV-negative HNSCC by transforming mouse primary tonsil epithelial cells with either HPV oncogenes or a nonantigenic RNA interference strategy that affects similar oncogenic pathways. To examine the effect of radiation therapy on HPV-positive and HPV-negative tumors in immune-competent and immune-incompetent mice and to examine responses in human...

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Source: Cancer Weekly (2009-12-29)

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