"Increasing evidence indicates that enhanced intratumoralandrogen synthesis contributes to prostate cancer progression after androgen deprivation therapy. This phase II study was designed to assess responses to blocking multiple steps in androgen synthesis with inhibitors of CYP17A1 (ketoconazole) and type I and II 5 alpha-reductases (dutasteride) in patients with castration-resistant prostatecancer (CRPC)," scientists writing in the journal Clinical Cancer Research report.
"Fifty-seven men with CRPC were continued on gonadal suppression and treated with ketoconazole (400 mg thrice daily), hydrocortisone (30 mg/AM, 10 mg/PM), and dutasteride (0.5 mg/d)....
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