Prostate Cancer
Recent findings from M.E. Taplin and co-authors highlight research in prostate cancer
Published in Cancer Weekly, January 5th, 2010
"Increasing evidence indicates that enhanced intratumoral androgen synthesis contributes to prostate cancer progression after androgen deprivation therapy. This phase II study was designed to assess responses to blocking multiple steps in androgen synthesis with inhibitors of CYP17A1 (ketoconazole) and type I and II 5 alpha-reductases (dutasteride) in patients with castration-resistant prostate cancer (CRPC)," scientists writing in the journal Clinical Cancer Research report.
"Fifty-seven men with CRPC were continued on gonadal suppression and treated with ketoconazole (400 mg thrice daily), hydrocortisone (30 mg/AM, 10 mg/PM), and dutasteride (0.5 mg/d)....
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Source: Cancer Weekly (2010-01-05)
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