Proteomics

New proteomics findings from B. Jullienne and co-researchers published

Published in Cancer Weekly, January 5th, 2010

Data detailed in 'Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid' have been presented. According to recent research from France, "Adenovirus (Ad)-mediated delivery of anti-angiogenic molecules into tumors constitutes an appealing approach for growth inhibition. However, lack of expression on tumors of Ad receptors leads to weak tumor transduction."

"Therefore, to provide Ad with a new entry pathway into tumors, an NGR peptide was inserted into either fiber (AdFNGR) or hexon (AdHNGR) capsid proteins. This strategy provided Ad with a very efficient entry pathway in both endothelial cells and tumor cells,...

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Source: Cancer Weekly (2010-01-05)

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