Rectal Cancer
New rectal cancer research from University Hospital discussed
Published in Cancer Weekly, January 12th, 2010
Researchers in Leuven, Belgium conducted a study "To assess the feasibility and efficacy of the COX-2 inhibitor celecoxib in conjunction with pre-operative chemoradiation for patients with locally advanced rectal cancer in a double blind randomized phase II study. Thirty-five patients of the initially planned 80 patients with locally advanced rectal cancer were treated with preoperative radiation (45 Gy; 1.8 Gy/fraction, 5 days/week) combined with 5-fluorouracil (continuous infusion, 225 mg/m(2)/day) and celecoxib (2 x 400 mg/day) or placebo."
"Pathological response and toxicity of study treatment were evaluated, as well as expression of COX-2 and Ki67 in tumor tissue...
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Source: Cancer Weekly (2010-01-12)
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