DNA Research

Findings from University of California advance knowledge in DNA research

Published in Cancer Weekly, January 26th, 2010

According to a study from the United States, "DNA polymerase delta (Pol delta) is a multisubunit polymerase that plays an indispensable role in replication from yeast to humans. Pol delta from Saccharomyces cerevisiae is composed of three subunits: Pol3, Pol31, and Pol32."

"Despite the elucidation of the structures and models of the individual subunits (or portions, thereof), the nature of their assembly remains unclear. We present here a small-angle X-ray scattering analysis of a yeast Pol delta complex (Pol delta(T)) composed of Pol3, Pol31, and Pol32N (amino acids 1-103 of Pol32). From the small angle X-ray scattering global parameters and reconstructed envelopes, we...

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Source: Cancer Weekly (2010-01-26)

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