Glioblastoma
New glioblastoma study findings have been reported by scientists at National Institutes of Health
Published in Cancer Weekly, January 26th, 2010
"EP4 expression in human glioblastoma cells correlates with growth on soft agar. The cyclooxygenase inhibitor sulindac sulfide first altered specificity protein-1 (Sp-1) and early growth response gene-1 expression, then increased the expression of nonsteroidal anti-inflammatory drug-activated gene 1 and activating transcription factor 3, and then decreased EP4 expression," scientists writing in the journal Cancer Prevention Research report.
"EP4 suppression was dependent on blocking the Sp-1 binding sites in the human EP4 promoter. Mutation in the Sp-1 sites in EP4 altered the promoter activity and abolished sulindac sulfide effects. The inhibitory effect of...
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Source: Cancer Weekly (2010-01-26)
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