Melanoma

Research from Yale University, Medical Department provides new data about melanoma

Published in Cancer Weekly, January 26th, 2010

According to recent research from the United States, "Fusion of cancer cells with migratory bone-marrow-derived cells such as macrophages can produce cancer cells with increased metastatic potential. To study this, we fused mouse macrophages with weakly metastatic mouse melanoma cells and generated a panel of hybrid clones."

"About half of these showed increased metastatic potential in mice. These hybrids expressed traits and molecules that were known indicators of tumor progression in melanoma (chemotaxis toward fibronectin, melanogenesis, autophagy, cMet, MCR1, SPARC, cell surface LAMP-1, GnT-V and beta 1,6-branched oligosaccharides). Here, we investigated integrin...

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Source: Cancer Weekly (2010-01-26)

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