Merkel Cell Cancer

Researchers from University of Helsinki report details of new studies and findings in the area of merkel cell cancer

Published in Cancer Weekly, January 26th, 2010

"Merkel cell carcinoma (MCC) is an aggressive cutaneous tumor with poor outcome and increasing incidence. We examined by immunohistochemistry the expression of three novel matrix metalloproteinases (MMPs)-MMP-21, MMP-26, and MMP-28-in 44 primary MCC tumors and six lymph node metastases while MMP-10 served as a positive control," scientists in Helsinki, Finland report.

"Their mRNA expression was also studied in the UISO MCC cell line basally and after various stimulations using quantitative real-time PCR. MMP-28 was observed in tumor cells of 15/44 samples especially in tumors < 2 cm in diameter (p = 0.015) while 21/44 specimens showed MMP-28 in the tumor stroma....

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Source: Cancer Weekly (2010-01-26)

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