Metabolism
New data from University of Toronto illuminate research in metabolism
Published in Cancer Weekly, January 26th, 2010
According to recent research published in the journal Cancer Epidemiology Biomarkers & Prevention, "Although expired carbon monoxide (CO) and plasma cotinine (COT) have been validated as biomarkers of self-reported cigarettes per day (CPD) in heavy smoking Caucasians, their utility in light smokers is unknown. Further, variability in CYP2A6, the enzyme that mediates formation of COT from nicotine and its metabolism to trans-3'-hydroxycotinine (3HC), may limit the usefulness of COT."
"We assessed whether CO and COT are correlated with CPD in African-American light smokers (<= 10 CPD, n = 700), a population with known reduced CYP2A6 activity and slow COT...
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Source: Cancer Weekly (2010-01-26)
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