Non-Small Cell Lung Cancer

Reports from St. James Hospital highlight recent research in non-small cell lung cancer

Published in Cancer Weekly, January 26th, 2010

According to recent research published in the European Journal of Cancer, "Cyclooxygenase (COX)-2 is frequently overexpressed in non-small cell lung cancer (NSCLC) and results in increased levels of prostaglandin E2 (PGE(2)), an important signalling molecule implicated in tumourigenesis. PGE(2) exerts its effects through the E prostanoid (EP) receptors (EPs1-4)."

"The expression and epigenetic regulation of the EPs were evaluated in a series of resected fresh frozen NSCLC tumours and cell lines. EP expression was dysregulated in NSCLC being up and downregulated compared to matched control samples. For EPs1, 3 and 4 no discernible pattern emerged. EP2 mRNA however...

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Source: Cancer Weekly (2010-01-26)

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