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Prostate Cancer

Research results from University of Alabama update knowledge of prostate cancer

Published in Cancer Weekly, January 26th, 2010

"Current evidence indicates that an osteoblast lesion in prostate cancer is preceded by osteolysis. Thus, prevention of osteolysis would reduce complications of bone metastasis," investigators in the United States report.

"Bone marrow-derived mesenchymal stem cells have the ability to differentiate into osteoblast and produce osteoprotegerin, a decoy receptor for the receptor activator for nuclear factor k B ligand, naturally. The present study examined the potential of unmodified mesenchymal stem cells to prevent osteolytic bone lesions in a preclinical mouse model of prostate cancer. The human prostate cancer cell line PC3 was implanted in tibiae of severe combined...

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