Solid Cancer

Studies from L. Santoro and co-researchers in the area of solid cancer published

Published in Cancer Weekly, January 26th, 2010

"We have previously shown that, in vitro, monoclonal antibodies (mAbs) labeled with the Auger electron emitter I-125 are more cytotoxic if they remain at the cell surface and do not internalize in the cytoplasm. Here, we assessed the in vivo biologic efficiency of internalizing and noninternalizing I-125-labeled mAbs for the treatment of small solid tumors," investigators in Montpellier, France report.

"Swiss nude mice bearing intraperitoneal tumor cell xenografts were injected with 37 MBq (370 MBq/mg) of internalizing (anti-HER1) I-125-m225 or noninternalizing (anti-CEA) I-125-35A7 mAbs at days 4 and 7 after tumor cell grafting. Nonspecific toxicity was assessed using...

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Source: Cancer Weekly (2010-01-26)

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