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Ulcers

Findings from Aga Khan University provide new insights into ulcers

Published in Cancer Weekly, January 26th, 2010

According to a study from Karachi, Pakistan, "Helicobacter pylori (H. pylori) infection is known to be associated with a spectrum of gastroduodenal diseases. We studied the association of H. pylori virulence markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA) alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma (GC) and duodenal ulcer (DU). H. pylori infection established by both rapid urease test and histology were studied."

"The cagA and vacA allelic status was determined by polymerase chain reaction (PCR). Sequencing of vacA i1 and i2 PCR product was carried out. Two hundred and twenty-four...

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