Bioengineering

Reports from University Medical Center advance knowledge in bioengineering

Published in Cancer Weekly, January 26th, 2010

"A significant fraction of HER2-overexpressing breast cancers exhibit resistance to the HER2 antibody trastuzumab. Hyperactivity of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway confers trastuzumab resistance, and mammalian target of rapamycin (mTOR) is a major downstream effector of PI3K/AKT," scientists in the United States report.

"Therefore, we examined whether mTCR inhibitors synergize with trastuzumab. Immunocompetent mice bearing HER2(+) mammary tumors were treated with trastuzumab, the mTOR inhibitor rapamycin, or the combination. Mice were imaged for tumor cell death using an optical Annexin-V probe and with [F-18] FDG positron emission tomography. The...

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Source: Cancer Weekly (2010-01-26)

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