Melanoma
Studies from University Federal of Sao Paulo have provided new data on melanoma
Published in Cancer Weekly, January 26th, 2010
Data detailed in 'Telomere-centromere-driven genomic instability contributes to karyotype evolution in a mouse model of melanoma' have been presented. "Aneuploidy and chromosomal instability (CIN) are hallmarks of most solid tumors. These alterations may result from inaccurate chromosomal segregation during mitosis, which can occur through several mechanisms including defective telomere metabolism, centrosome amplification, dysfunctional centromeres, and/or defective spindle checkpoint control," investigators in Sao Paulo, Brazil report.
"In this work, we used an in vitro murine melanoma model that uses a cellular adhesion blockade as a transforming factor to...
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Source: Cancer Weekly (2010-01-26)
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