Mantle Cell Lymphoma Therapy
Study findings from Ohio State University, Center for Biostatistics provide new insights into mantle cell lymphoma therapy
Published in Cancer Weekly, February 2nd, 2010
Fresh data on mantle cell lymphoma are presented in the report 'Flavopiridol, fludarabine, and rituximab in mantle cell lymphoma and indolent B-cell lymphoproliferative disorders.' "Flavopiridol downmodulates antiapoptotic proteins associated with resistance to fludarabine and rituximab and is effective against p53-mutated chronic lymphocytic leukemia (CLL). We conducted a phase I study of flavopiridol, fludarabine, and rituximab (FFR) in patients with mantle-cell lymphoma (MCL), indolent B-cell non-Hodgkin's lymphomas (B-NHL), and CLL to determine the activity of FFR," investigators in the United States report.
"Therapy included fludarabine 25 mg/m2...
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Source: Cancer Weekly (2010-02-02)
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