Life Sciences

Reports outline life sciences research from University of Colorado

Published in Cancer Weekly, February 2nd, 2010

According to recent research from the United States, "Doxazolidine (Doxaz) is a functionally distinct formaldehyde conjugate or doxorubicin (Dox) that induces cancer cell death in Dox-sensitive and resistant cells. Pentyl PABC-Doxaz (PPD) is a prodrug or Doxaz that is activated by carboxylesterase 2 (CES2), which is expressed by liver, non-small-cell lung, colon, pancreatic, renal, and thyroid cancer cells."

"Here, we demonstrate that in two murine models, PPD was effective at slowing tumor growth and demonstrated markedly reduced cardiotoxic and nephrotoxic effects, as well as better tolerance, relative to Dox. Hepatotoxicity, consistent with liver expression of the...

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Source: Cancer Weekly (2010-02-02)

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