Astrocytoma

University of Utah reports research in astrocytoma in children

Published in Cancer Weekly, February 2nd, 2010

New research, 'Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas,' is the subject of a report. "Malignant astrocytomas are a deadly solid tumor in children. Limited understanding of their underlying genetic basis has contributed to modest progress in developing more effective therapies," scientists writing in the journal Cancer Research report.

"In an effort to identify such alterations, we performed a genome-wide search for DNA copy number aberrations (CNA) in a panel of 33 tumors encompassing grade 1 through grade 4 tumors. Genomic amplifications of 10-fold or greater were restricted to grade 3...

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Source: Cancer Weekly (2010-02-02)

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