Gene Therapy
Research reports on gene therapy from University of Minnesota, Cancer Center provide new insights
Published in Cancer Weekly, February 2nd, 2010
Researchers detail in 'The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency,' new data in gene therapy. According to a study from the United States, "Dmrt1 (doublesex and mab-3 related transcription factor 1) is a conserved transcriptional regulator of male differentiation required for testicular development in vertebrates. Here, we show that in mice of the 129Sv strain, loss of Dmrt1 causes a high incidence of teratomas, whereas these tumors do not form in Dmrt1 mutant C57BL/6J mice."
"Conditional gene targeting indicates that Dmrt1 is required in fetal germ cells but not in Sertoli cells to prevent teratoma...
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Source: Cancer Weekly (2010-02-02)
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