Researchers detail in 'The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency,' new data in gene therapy. According to a study from the United States, "Dmrt1 (doublesex and mab-3 related transcription factor 1) is a conserved transcriptional regulator of male differentiation required for testicular development in vertebrates. Here, we show that in mice of the 129Sv strain, loss of Dmrt1 causes a high incidence of teratomas, whereas these tumors do not form in Dmrt1 mutant C57BL/6J mice."
"Conditional gene targeting indicates that Dmrt1 is required in fetal germ cells but not in Sertoli cells to prevent teratoma...
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