Genetics

Recent findings from Netherlands Cancer Institute highlight research in genetics

Published in Cancer Weekly, February 2nd, 2010

A new study, 'Recombination-induced tag exchange to track old and new proteins,' is now available. "The dynamic behavior of proteins is critical for cellular homeostasis. However, analyzing dynamics of proteins and protein complexes in vivo has been difficult," investigators in Netherlands report.

"Here we describe recombination-induced tag exchange (RITE), a genetic method that induces a permanent epitope-tag switch in the coding sequence after a hormone-induced activation of Cre recombinase. The time-controlled tag switch provides a unique ability to detect and separate old and new proteins in time and space, which opens up opportunities to investigate the dynamic...

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Source: Cancer Weekly (2010-02-02)

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