Leukemia
Pennsylvania State University, Cancer Institute describes research in leukemia
Published in Cancer Weekly, February 2nd, 2010
Current study results from the report, 'Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway,' have been published. According to a study from the United States, "Large granular lymphocyte (LGL) leukemia results from chronic expansion of cytotoxic T cells or natural killer (NK) cells. Apoptotic resistance resulting from constitutive activation of survival signaling pathways is a fundamental pathogenic mechanism."
"Recent network modeling analyses identified platelet-derived growth factor (PDGF) as a key master switch in controlling these survival pathways in T-cell LGL leukemia. Here we show that an...
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Source: Cancer Weekly (2010-02-02)
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