Squamous Cell Carcinoma

Studies from Kaohsiung Medical University yield new information about squamous cell carcinoma

Published in Cancer Weekly, March 2nd, 2010

According to recent research from Kaohsiung, Taiwan, "BUBR1 is one of the key components of the spindle assembly checkpoint ( SAC) machinery and is activated in response to kinetochore tension. Defects in the SAC contribute to an increased rate of aneuploidization during tumorigenesis."

"The aim of the present study was to examine the immunohistochemical expression of BUBR1 protein for human oral squamous cell carcinogenesis. A total of 120 samples of squamous cell carcinoma (SCC, n = 43) and 5 types of potentially malignant disorders (PMDs: oral epithelial dysplasia, n = 11; hyperkeratosis/epithelial hyperplasia, n = 20; lichen planus, n = 16; submucous fibrosis, n =...

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Source: Cancer Weekly (2010-03-02)

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