Non-Small Cell Lung Cancer

Reports from J.C. Ko and colleagues advance knowledge in non-small cell lung cancer

Published in Cancer Weekly, March 9th, 2010

According to recent research published in the journal Biochemical Pharmacology, "Emodin, a tyrosine kinase inhibitor, is a natural anthraquinone derivative found in the roots and rhizomes of numerous plants. Emodin exhibits anticancer effects against a variety of cancer cells, including lung cancer cells."

"ERCC1 and Rad51 proteins are essential for nucleotide excision repair and homologous recombination, respectively. Furthermore, ERCC1 and Rad51 overexpression induces resistance to DNA-damaging agents that promote DNA double-strand breaks. Accordingly, the aim of this study was to determine the role of ERCC1 and Rad51 in emodin-mediated cytotoxicity in human...

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Source: Cancer Weekly (2010-03-09)

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