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Lung Cancer

Data on lung cancer discussed by researchers at Hamamatsu University, Department of Internal Medicine

Published in Cancer Weekly, March 16th, 2010

Investigators publish new data in the report 'Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer.' According to recent research published in the journal Lung Cancer, "Indoleamine 2,3-dioxygenase (IDO) catalyzes the rate-limiting step of tryptophan (Trp) degradation along the kynurenine (Kyn) pathway. By depleting tryptophan, IDO is considered to be a fundamental immune escape mechanism for tumor cells."

"However, IDO expression in lung cancer has not been explored thoroughly. Thus, the present study investigated IDO activity determined by serum Trp and Kyn concentrations in lung cancer and the correlation between the...

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