Neuroblastoma Risk Factors

Scientists at Memorial Sloan-Kettering Cancer Center, Department of Medicine publish research in neuroblastoma risk factors

Published in Cancer Weekly, March 30th, 2010

Data detailed in 'KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma' have been presented. "NK cells exhibit cytotoxicity against neuroblastoma. Gene polymorphisms governing NK cell function, therefore, may influence prognosis," scientists in the United States report.

"Two highly polymorphic genetic loci instrumental in determining NK cell responses encode the NK cell killer immunoglobulin-like receptors (KIR) and their class I human leukocyte antigen (HLA) ligands. We hypothesized that patients with a 'missing ligand' KIR-HLA compound genotype may uniquely...

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Source: Cancer Weekly (2010-03-30)

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