Rhabdoid Tumors Cell Biology
Findings from University of North Carolina, Lineberger Comprehensive Cancer Center broaden understanding of rhabdoid tumors cell biology
Published in Cancer Weekly, March 30th, 2010
New research, 'Reexpression of hSNF5 in malignant rhabdoid tumor cell lines causes cell cycle arrest through a p21(CIP1/WAF1)-dependent mechanism,' is the subject of a report. "Loss of hSNF5 function is usually observed in malignant rhabdoid tumor (MRT), a highly aggressive pediatric neoplasm. Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A), p21(CIP1/WAF1), and cyclin D1 playing key roles in MRT cell growth control," scientists in the United States report.
"However, we have shown that reexpression of hSNF5 induced cell cycle arrest in the absence of p16(INK4A) expression. These results indicate that...
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Source: Cancer Weekly (2010-03-30)
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