Breast Cancer
Research in the area of breast cancer reported from University of North Carolina, Lineberger Comprehensive Cancer Center
Published in Cancer Weekly, March 30th, 2010
New research, 'Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha,' is the subject of a report. "The membrane bound receptor tyrosine kinase Her2 is overexpressed in approximately 30% of human breast cancers, which correlates with poor prognosis. Her2-induced signaling pathways include MAPK and PI3K/Akt, of which the latter has been shown to be critical for Her2(+) breast cancer cell growth and survival," scientists writing in the journal Oncogene report.
"In addition, the NF-kappaB pathway has been shown to be activated downstream of Her2 overexpression; however, the mechanisms leading to this activation are not...
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Source: Cancer Weekly (2010-03-30)
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