Colon Cancer Therapy

New colon cancer therapy study findings have been reported from Nara Medical University, Department of Molecular Pathology

Published in Cancer Weekly, March 30th, 2010

New research, 'HMGB1 attenuates anti-metastatic defense of the lymph nodes in colorectal cancer,' is the subject of a report. "Cancer-secreted high mobility group 1 (HMGB1) induces apoptosis of macrophages and suppresses the host anti-cancer immune system. We here examined the effect of HMGB1 on macrophages in the lymph nodes of colorectal cancer (CRC) patients," investigators in Nara, Japan report.

"Regional lymph nodes of 50 Dukes C CRCs were compared with 50 Dukes B CRCs. Dukes C tumors exhibited higher HMGB1 labeling indices and higher HMGB1 concentrations in primary tumors than Dukes B CRCs. Macrophages in the regional lymph nodes were decreased in non-metastasized...

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Source: Cancer Weekly (2010-03-30)

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