Life Sciences

Research from Beatson Institute for Cancer Research in the area of life sciences published

Published in Cancer Weekly, March 30th, 2010

Researchers detail in 'Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells,' new data in life sciences. "Dr1 (also known as NC2beta) was identified as a repressor of RNA polymerase (pol) II transcription. It was subsequently shown to inhibit pol III transcription when expressed at high levels in vitro or in yeast cells," scientists in Glasgow, the United Kingdom report.

"However, endogenous Dr1 was not detected at pol III-transcribed genes in growing yeast. In contrast, we demonstrate that endogenous Dr1 is present at pol III templates in human cells, as is its dimerization partner DRAP1 (also called NC2alpha). Expression of tRNA by pol...

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Source: Cancer Weekly (2010-03-30)

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