Melanoma Therapy

Research on melanoma therapy published by scientists at University of Toronto, Department of Pharmaceutical Sciences

Published in Cancer Weekly, March 30th, 2010

Data detailed in 'An evolved ribosome-inactivating protein targets and kills human melanoma cells in vitro and in vivo' have been presented. According to a study from Canada, "Few treatment options exist for patients with metastatic melanoma, resulting in poor prognosis. One standard treatment, dacarbazine (DTIC), shows low response rates ranging from 15 to 25 percent with an 8-month median survival time."

"The development of targeted therapeutics with novel mechanisms of action may improve patient outcome. Ribosome-inactivating proteins (RIPs) such as Shiga-like Toxin 1 (SLT-1) represent powerful scaffolds for developing selective anticancer agents. Here we report the...

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Source: Cancer Weekly (2010-03-30)

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