Bone Morphogenetic Protein
Studies from University of Wisconsin provide new data on bone morphogenetic protein
Published in Cancer Weekly, April 6th, 2010
According to recent research from the United States, "Stromal-epithelial signaling is a critical regulator of normal prostate development and has been speculated to play an equally important role in the development and progression of prostate cancer. Sonichedgehog (Shh) and bone morphogenetic proteins (BMP-4, BMP-7), expressed by the urogenital sinus epithelium and mesenchyme, exert reciprocal and coordinate effects on outgrowth of nascent prostate ducts."
"Over-expression of Shh in the LNCaP xenograft was shown previously to accelerate tumor growth by a paracrine mechanism. A survey of BMP regulators expressed in the developing prostate revealed increased Noggin and...
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Source: Cancer Weekly (2010-04-06)
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